US 7,125,853 B2 · Bicyclic carbohydrate compounds useful in the treatment of infections caused by Flaviviridae sp., such as hepatitis C and bovine viral diarrhea viruses

Abstract

We describe the use of bicyclic carbohydrates for the treatment of hepatitis C virus infections. Different bicyclic carbohydrates were tested in vitro against DNA-viruses, retro-viruses and Flaviviridae sp., an important family of human and animal RNA pathogens. Significant activity was observed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), the bicyclic carbohydrates in general and the preferred bicyclic carbohydrates more specifically are expected to be a treatment for hepatitis C viral infections.

Claims5

Dependent claims

A method of treating infections caused by Flaviviridae sp., comprising the step of administering an effective amount of a bicyclic carbohydrate having the formula:

wherein:
R1 is selected from the group consisting of -alkyl, -aryl and -benzyl;
R2 and R3 are selected from the group consisting of -alkyl and -aryl;
R4 is an -aryl;
and
X is O;
or a pharmaceutically active salt thereof.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/743,111Filed 22 Dec 2003 · us provisional application

Priority

7 Jan 2003

Published

US 2004/0209823 A121 Oct 2004

Granted

24 Oct 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07D 493/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61K 31/357
Having oxygen as the only ring hetero atom, e.g. fungichromin: having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
A61K 31/385
Having sulfur as a ring hetero atom: having two or more sulfur atoms in the same ring
A61K 31/519
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with heterocyclic rings

Bicyclic carbohydrate compounds useful in the treatment of infections caused by Flaviviridae sp., such as hepatitis C and bovine viral diarrhea viruses

Life of this patent

Bicyclic carbohydrate compounds useful in the treatment of infections caused by Flaviviridae sp., such as hepatitis C and bovine viral diarrhea viruses

Life of this patent

Abstract

Claims5