Mechanically activated channel blocker
AssigneeThe Research Foundation of State University of New York at Buffalo
InventorsFrederick Sachs, Thomas Suchyna, Janice Johnson
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Abstract
The present invention discloses a peptide of SEQ ID NO:2 and its variants that blocks stretch-activated ion channels. The peptide, designated as GsMTx-4, is present in the venom of the spider Grammostola spatulata. The present invention also discloses a method of purifying the peptide GsMTx-4 from the spider venom and a method for inhibition of stretch activated ion channels in a cell. The cDNA sequence encoding the GsMTx-4 is also disclosed. This peptide and its variants can be used for the treatment of cardiac arrhythmias.
Claims14
An isolated and purified peptide comprising the sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3.
Dependencies are inferred from the claim text.