Anti-fungal compounds and methods of use
AssigneeCanBas Co., Ltd.
InventorsTakumi Kawabe, Hidetaka Kobayashi
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds including peptides and peptidomimetics having anti-fungal activity alone, and in combination with other agents that have anti-fungal activity. The invention includes the use of cell cycle G2 checkpoint abrogators as anti-fungal agents, such as anti-fungal medicine.
Claims61
A method of inhibiting or reducing fungal infection or fungal growth, comprising contacting the fungus or an object in contact with the fungus with an amount of a peptide or peptidomimetic comprising a sequence defined as:
- (i) P6-P5-P4-P3-P2-P1;
- wherein
- P1 is d- or l-Cha;
- P2 is d- or l-Bpa, d- or l-Phe4NO2;
- P3 is any amino acid;
- P4 is d- or l-tryptophan;
- P5 is any amino acid;
- and
- P6 is d- or l-Bpa, d- or l-Phe4NO2;
- (ii) or a prodrug thereof, sufficient to inhibit or reduce fungal infection or fungal growth.
A method of inhibiting or reducing contamination of an object or organism with a fungus comprising contacting the object or organism with an amount of a compound including a peptide or peptidomimetic comprising a sequence defined as:
- (i) P6-P5-P4-P3-P2-P1;
- wherein P1 is d- or l-Cha;
- P2 is d- or l-(Phe-2,3,4,5,6-F), d- or l-Bpa, d- or l-Phe4NO2;
- P3 is any amino acid;
- P4 is d- or l-tryptophan;
- P5 is any amino acid;
- and
- P6 is d- or l-Bpa, d- or l-Phe4NO2;
- (ii) or a prodrug thereof, sufficient to inhibit or reduce contamination of the object or organism.
A method of treating fungal growth or fungal infection, comprising administering to a subject having or at risk of having fungal growth or fungal infection an amount of a compound comprising a sequence defined as:
- (i) P6-P5-P4-P3-P2-P1;
- wherein P1 is d- or l-Cha;
- P2 is d- or l-(Phe-2,3,4,5,6-F), d- or l-Bpa, d- or l-Phe4NO2;
- P3 is any amino acid;
- P4 is d- or l-tryptophan;
- P5 is any amino acid;
- and
- P6 is d- or l-Bpa, d- or l-Phe4NO2;
- (ii) or a prodrug thereof, effective to treat fungal growth or fungal infection.
A method of treating fungal growth, contamination or infection, comprising contacting a plant, plant part or seed having or at risk of having fungal growth, contamination or infection, with an amount of a sequence defined as:
- (i) P6-P5-P4-P3-P2-P1;
- wherein P1 is d- or l-Cha;
- P2 is d- or l-(Phe-2,3,4,5,6-F), d- or l-Bpa, d- or l-Phe4NO2;
- P3 is any amino acid;
- P4 is d- or l-tryptophan;
- P5 is any amino acid;
- and
- P6 is d- or l-Bpa, d- or l-Phe4NO2;
- (ii) or a prodrug thereof, effective to treat the fungal growth, contamination or infection.
Dependencies are inferred from the claim text.