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US 7,125,683 B2Granted
Preparations for diagnosis extrapancreatic secretory function
AssigneeTokyo Gas Co., Ltd.
InventorsIto Asuka, Tadashi Kohno, Isaburo Hosoi, Junko Hirayama, Kunihiko Shibata, Kenji Maeda
Life of this patent
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Abstract
A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into the blood and/or is excreted out of the body, wherein the substance is carried by a carrier and released from the carrier when exposed to the action of a pancreatic exocrine function-related factor.
Claims13
A method for diagnosis of pancreatic exocrine function, comprising:
- administering to a subject a carrier containing a 13C-labeled substance, said carrier being a substrate for a pancreatic exocrine enzyme and containing an amide bond, a peptide bond, or a α-1, 4-glycoside bond, said 13C-labeled substance being released from the carrier when exposed to an action of the pancreatic exocrine function enzyme;
- and
- determining an amount of the substance administered to a subject or a degradation product or metabolite of the substance that migrated into the blood and/or is excreted out of the body of the subject to ascertain a level of the pancreatic exocrine function of the subject.
A method for diagnosis of pancreatic exocrine function, comprising:
- administering to a subject a carrier containing a 13C-labeled substance, said carrier being a substrate for a protease or an amylase, said 13C-labeled substance being released from the carrier when exposed to an action of the protease or the amylase;
- and
- determining an amount of the substance administered to a subject or a degradation product or metabolite of the substance that migrated into the blood and/or is excreted out of the body of the subject, to ascertain a level of the pancreatic exocrine function of the subject.
Dependencies are inferred from the claim text.