Methods for detection of disease-associated antibodies in urine
AssigneeLudwig Institute for Cancer Research
InventorsAlexander Knuth, Elke Jäger, Dirk Jäger
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Abstract
The present invention provides methods and diagnostic kits for the detection of disease-specific antibodies in urine containing sample. The present invention is also directed toward methods for determining that a patient suffers from a disorder characterized by aberrant expression of a naturally occurring gene. Methods for monitoring the status of a disorder in a patient characterized by aberrant expression of a naturally occurring gene are also provided.
Claims4
A method for determining that a patient suffers from a cancer characterized by aberrant expression of a cancer-testis (CT) antigen, consisting of:
- i) contacting a urine containing sample from a patient that is believed to suffer from said cancer with a cancer-testis (CT) antigen that specifically binds to an antibody present in said urine and characteristic of said cancer, under conditions favoring complex formation between the cancer-testis (CT) antigen and the antibody;
- and
- ii) detecting the complex between the cancer-testis (CT) antigen and the antibody present in said urine,
- wherein presence of the antibody, as indicated by formation and detection of the complex indicates that the patient suffers from said cancer, wherein the cancer-testis (CT) antigen is NY-ESO-1 (SEQ ID NO:1), the protein encoded by the nucleic acid sequence of SEQ ID NO:
- 2 (SCP-1) or the protein encoded by the nucleic acid sequence of SEQ ID NO:
- 3 (clone 18CGI1F2).
A method for determining that a patient suffers from a cancer characterized by aberrant expression of a cancer-testis (CT) antigen, comprising:
- i) contacting a urine containing sample from a patient that is believed to suffer from said cancer with a cancer-testis (CT) antigen tat specifically binds to an antibody present in said urine and characteristic of said cancer, under conditions favoring complex formation between the cancer-testis (CT) antigen and the antibody;
- and
- ii) detecting the complex between the cancer-testis (CT) antigen and the antibody present in said urine,
- wherein presence of the antibody, as indicated by formation and detection of the complex indicates that the patient suffers from said cancer, wherein the cancer-testis (CT) antigen is NY-ESO-1 (SEQ ID NO:1), the protein encoded by the nucleic acid sequence of SEQ ID NO:
- 2 (SCP-1) or the protein encoded by the nucleic acid sequence of SEQ ID NO:
- 3 (clone 18CGI1F2).
Dependencies are inferred from the claim text.