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US 7,125,677 B2Granted
NIMA interacting proteins
AssigneeThe Salk Institute for Biological Studies
InventorsTony Hunter, Kun Ping Lu
Life of this patent
Estimating the term…
Abstract
A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.
Claims7
A method of detecting Pin1 protein in a cell sample, comprising contacting a cell sample with an antibody that selectively binds to a Pin1 protein having the amino acid sequence as set forth in SEQ ID NO:
- 2, and determining whether said antibody binds to said cell sample, wherein binding of said antibody to said cell sample is indicative of the presence of Pin1 protein in said cell sample.
Dependencies are inferred from the claim text.