Removal of plasmin(ogen) from protein solutions
AssigneeOmrix Biopharmaceuticals Ltd.
InventorsIsrael Nur, Liliana Bar, Malkit Azachi
Life of this patent
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Abstract
A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6–8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
Claims8
A method for specifically removing or isolating plasminogen or plasmin from a mixture containing plasminogen or plasmin in the presence of fibrinogen comprising
- contacting the mixture with tranexamic acid covalently bound to sepharose via the amino group of the tranexamic acid wherein the tranexamic acid is bound to sepharose via an epoxy linker between the support and the tranexamic acid, such that the plasminogen or plasmin binds to tranexamic acid bound to the support, followed by
- separating the support-bound plasminogen or plasmin from the mixture.
Dependencies are inferred from the claim text.