Lipophilic drug compositions
OwnerMichael T. Sunginventor
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Abstract
The invention is directed to biologically active lipophilic compositions comprising a biologically active covalently attached to, or encapsulated within, a lipid. Preferably, a biologically active agent is both covalently attached to a lipid and encapsulated within a lipid composition. Preferred lipid components include triglycerides and fatty acids. The resulting composition is preferably adapted for oral administration.
Claims19
A biologically active lipophilic composition, comprising a biologically active agent covalently attached to a non-amphipathic lipid through a linkage to form a lipophilic conjugate, wherein the lipid attached to the biologically active agent is selected from the group consisting of fatty acids and esters thereof and the linkage is hydrolytically stable in aqueous solution at physiologic pH and enzymatically cleavable, and a non-amphipathic lipid composition encapsulating the lipophilic conjugate, wherein the encapsulating lipid composition consists essentially of one or more lipids selected from the group consisting of fatty acids, esters of fatty acids, and mixtures thereof.
A solid biologically active lipophilic composition adapted for oral administration, comprising a biologically active agent covalently attached to a non-amphipathic lipid selected from the group consisting of fatty acids and esters thereof, and a non-amphipathic lipid composition encapsulating the lipophilic conjugate, wherein the encapsulating lipid composition consists essentially of one or more lipids selected from the group consisting of fatty acids, esters or fatty acids, and mixtures thereof.
Dependencies are inferred from the claim text.