Composition improved in the solubility or oral absorbability
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsJun Sugishita, Makoto Kigoshi, Setsuko Yano, Hideki Morita, Yasuki Kato
Life of this patent
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Abstract
An object of the present invention is to provide a composition improved in the solubility or oral absorbability. The present invention provides a composition which comprises three components of a slightly water-soluble component, a surfactant and a hydrophilic polymer, and is obtainable by wet granulation in the presence of water.
Claims32
A composition which comprises three components of a medicament, a surfactant and a hydrophilic polymer, and is obtained by wet granulating in the presence of water, wherein the medicament is a compound represented by formula (I):
- wherein R represents NR1R2, in which R1 and R2 are the same or different and each represents hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group, or R1 and R2 form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom, or formula (II):
- wherein R3 and R4 are the same or different and each represents substituted or unsubstituted alkyl;
- and R5 represents substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted bicycloalkyl, or substituted or unsubstituted tricycloalkyl.
A method for manufacturing of a composition which comprises three components of a medicament, a surfactant and a hydrophilic polymer comprising the steps of:
- wet granulating the medicament together with the surfactant and the hydrophilic polymer in the presence of water, wherein the medicament is a compound represented by formula (I);
- wherein R represents NR1R2, in which R1 R2 are the same or different and each re resents hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group, or R1 and R2 form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom, or formula (II):
- wherein R3 and R4 are the same or different and each represents substituted or unsubstituted alkyl;
- and R5 represents substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted bicycloalkyl, or substituted or unsubstituted tricycloalkyl.
Dependencies are inferred from the claim text.