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US 7,125,562 B2Granted
Rapidly disintegrating methylcellulose tablets
AssigneeSmithKline Beecham Corporation
InventorsBruce Daggy, Naresh I Mehta, Priyashri Nayak
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Abstract
The present invention relates to a rapidly disintegrating tablet for oral administration. The tablet has a first phase and a second phase blended with the first phase. The first phase has a compacted mixture of methylcellulose having a viscosity of >1000 centipoise and a diluent. The methylcellulose is the sole active ingredient in the first phase. There is also a process for preparing a rapidly disintegrating tablet.
Claims34
A rapidly disintegrating tablet for oral administration comprising
- a first phase having a compacted mixture of methylcellulose with a viscosity of >1000 centipoise, and a diluent, wherein the methylcellulose is the sole active, wherein the diluent is an edible calcium salt;
- and
- a second phase that is blended with the first phase wherein the second phase includes at least two ingredients selected from the group consisting of a disintegrating agent, a wetting agent, a lubricant, and a second diluent.
A process of preparing a rapidly disintegrating tablet comprising
- granulating methylcellulose and granulating a diluent, wherein the diluent is an edible calcium salt
- blending the granulated methylcellulose and the granulated diluent together to form a first phase;
- blending a second phase including at least two ingredients selected from the group consisting of a disintegrating agent, a wetting agent, a lubricant, and a second diluent;
- mixing together the first phase and the second phase to form the tablet.
1 more element
Dependencies are inferred from the claim text.