Compartmentalized dosage form
AssigneeEuro-Celtique S.A.
InventorRichard S. Sackler
Life of this patent
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Abstract
The present invention provides provide a dosage form that prevents misuse of the medicament contained within. The dosage form contains an inactivating substance in combination with the medicament, wherein the two substances are separated by a permeable or semi-permeable partition. The partition becomes impermeable upon activation by a medical professional, thereby effectively sequestering the inactivating substance from the medicament and allowing for the intended administration of the medicament to the patient. Unless activated, however, the inactivating substance and medicament remain commingled in the dosage form, and any attempt to dispense the medicament before activation will result in the release of inactivated medicament.
Claims2
A dosage form comprising
- (a) a first compartment comprising a medicament;
- (b) a second compartment comprising an inactivating agent;
- (c) a semi-permeable or permeable partition separating said first and second compartments;
- and
- (d) an outer layer surrounding said first and second compartments;
- and
- (e) a third compartment comprising a detection material which is released when the dosage form is crushed or dissolved,
- wherein said partition is rendered impermeable upon exposure to a stimulus selected from the group consisting of heat, microwave radiation, infra-red radiation, visual radiation, ultraviolet radiation, and ionizing electromagnetic radiation, such that said impermeable partition sequesters said medicament from said inactivating agent, and
- wherein said medicament is an opiate or benzodiazepine and the inactivating agent is selected from the group consisting of an opioid or benzodiazepine antagonist and an emetic.
Dependencies are inferred from the claim text.