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US 7,125,560 B2Granted
Pharmaceutical composition of topiramate
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsMadhav S. Thakur, Pramod M. Kotwal, Irwin S. Gibbs
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Abstract
The invention is directed to a pharmaceutical composition of topiramate, an anticonvulsant which is useful for treating epilepsy. More specifically, the present invention provides a solid dosage formulation of topiramate intended primarily for use by pediatric patients, or for patients who have difficulty swallowing tablets. Processes for preparing the pharmaceutical composition are also described.
Claims5
A method of treating convulsions in a mammal in need thereof which comprises administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising
- (a) core particles containing an active agent of topiramate, a binder and a diluent wherein the diluent is sugar spheres and wherein the core particles have an initial particle size between about 0.710 mm and 1.18 mm;
- and
- (b) a taste mask coating, wherein the taste mask coating comprises between about 9% by weight and about 13% by weight of the pharmaceutical composition and wherein the coated particles of the pharmaceutical composition have a final particle size between about 0.850 mm and 1.18 mm;
- and
- wherein the coated particles are sprinkled onto soft food and swallowed.
2 more elements
Dependencies are inferred from the claim text.