Cosmetic or dermatological composition comprising a combination of an elastase inhibitor of the N-acylaminoamide family and at least one myorelaxing agent

A cosmetic or dermatological composition comprising an N-acylaminoamide inhibitor of elastase and at least one myorelaxing agent, wherein the myorelaxing agent is at least one selected from the group consisting of a calcium channel inhibitor and a chloride channel agonist and wherein the N-acylaminoamide inhibitor of elastase is a compound of formula (I):

• in which:
• the Y radical represents O or S
• the R1 radical represents:
• (i) a hydrogen atom
• (ii) a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing from 1 to 18 carbon atoms, optionally substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• OH;
• —OR;
• —O—COR;
• —SH;
• —SR;
• —S—COR;
• —NH2;
• —NHR;
• —NRR′;
• —NH—COR;
• -Hal (halogen);
• —CN;
• —COOR;
• —COR;
• —P(O)—(OR)2;
• and —SO2—OR;
• with R and R′ each representing independently a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated, said R and R′ radicals being capable of forming together with N a 5- or 6- membered carbon ring that may include in addition at least one heteroatom selected from the group consisting of O, N and/or S in the ring, and/or may be substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR″;
• —O—COR″;
• —SH;
• —SR″;
• —S—COR″;
• —NH2;
• —NHR″;
• —NH—COR″;
• -Hal (halogen);
• —CN;
• —COOR″;
• —COR″;
• with R″ representing independently a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated,
• (iii) a radical selected from the group consisting of the radicals —OR;
• —NH2;
• —NHR;
• —NRR′;
• —NH—COR;
• —COOR;
• —COR;
• with R and R′ each representing independently a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated;
• said R and R′ radicals being capable of forming together with N a 5- or 6- membered carbon ring that may include in addition at least one heteroatom selected from the group consisting of O, N and/or S in the ring, and/or may be substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR″;
• —O—COR″;
• —SH;
• —SR″;
• —S—COR″;
• —NH2;
• —NHR″;
• —NH—COR″;
• -Hal (halogen);
• —CN;
• —COOR″;
• and —COR″;
• with R″ representing a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated,
• the radical R2 represents a hydrocarbon radical, linear, branched or cyclic saturated or unsaturated, containing 1 to 18 carbon atoms, optionally substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR;
• —O—COR;
• —SH;
• —SR;
• —S—COR;
• —NH2;
• —NHR;
• —NRR″;
• —NH—COR;
• -Hal (halogen);
• —CN;
• —COOR;
• and —COR;
• with R and R′ each representing independently a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated, said R and R′ radicals being capable of forming together with N a 5- or 6- membered carbon ring that may include in addition at least one heteroatom selected from the group consisting of O, N and/or S in the ring, and/or may be substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR″;
• —O—COR″;
• —SH;
• —SR″;
• —S—COR″;
• —NH2;
• —NHR″;
• —NH—COR″;
• -Hal (halogen);
• —CN;
• —COOR″;
• and —COR″;
• with R″ representing a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated,
• the radical R3 represents a radical selected from the group consisting of those of formula (II) or (III)
• —A—C6H(5−y)—By (II)
• —C6H(5−y)—By′ (III)
• in which:
• y is an integer included between 0 and 5, and y′ is an integer included between 1 and 5;
• A is a divalent hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 18 carbon atoms, optionally substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR;
• —O—COR;
• —SH;
• —SR;
• —S—COR;
• —NH2;
• —NHR;
• —NRR′;
• —NH—COR;
• -Hal (halogen);
• —CN;
• —COOR;
• —COR;
• —NO2;
• and —SO2—OR;
• with R and R′ each representing independently a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated, said R and R′ radicals being capable of forming together with N a 5- or 6- membered carbon ring that may include in addition at least one heteroatom selected from the group consisting of O, N and/or S in the ring, and/or may be substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR″;
• —O—COR″;
• —SH;
• —SR″;
• —S—COR″;
• —NH2;
• —NHR″;
• —NH—COR″;
• -Hal (halogen);
• —CN;
• —COOR″;
• and —COR″;
• with R″ representing a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated,
• B is a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 18 carbon atoms, optionally substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR;
• —O—COR;
• —SH;
• —SR;
• —S—COR;
• —NH2;
• —NHR;
• —NRR′;
• —NH—COR;
• -Hal (halogen);
• —CN;
• —COOR;
• —COR;
• —NO2;
• and —SO2—OR;
• with R and R′ each representing independently a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated;
• containing 1 to 6 carbon atoms, optionally halogenated, said R and R′ radicals being capable of forming together with N a 5- or 6- membered carbon ring that may include in addition at least one heteroatom selected from the group consisting of O, N and/or S in the ring, and/or may be substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR″;
• —O—COR″;
• —SH;
• —SR″;
• —S—COR″;
• —NH2;
• —NHR″;
• —NH—COR″;
• -Hal (halogen);
• —CN;
• —COOR″;
• and —COR″;
• with R″ representing a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated,
• the radical X represents a radical selected from the group consisting of
• —OH;
• —OR4, —NH2, —NHR4, —NR4R5, —SR4, —COOR4;
• and —COR4;
• with R4 and R5 each representing independently a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR;
• —O—COR;
• —SH;
• —SR;
• —S—COR;
• —NH2;
• —NHR;
• —NRR′;
• —NH—COR;
• -Hal (halogen);
• —CN;
• —COOR;
• and —COR;
• with R and R′ each representing independently a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated, said R and R′ radicals being capable of forming together with N a 5- or 6- membered carbon ring that may include in addition at least one heteroatom selected from the group consisting of O, N and/or S in the ring, and/or may be substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR″;
• —O—COR″;
• —SH;
• —SR″;
• —S—COR″;
• —NH2;
• —NHR″;
• —NH—COR″;
• -Hal (halogen);
• —CN;
• —COOR″;
• and —COR″;
• with R″ representing a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated,
• said R4 and R5 radicals being capable of forming together with N a 5- or 6 membered carbon ring that may include in addition at least one heteroatom selected from the group consisting of O, N and/or S in the ring, and/or may be substituted by 1 to 5 groups, identical or different, selected from the group consisting of
• —OH;
• —OR″;
• —O—COR″;
• —SH;
• —SR″;
• —S—COR″;
• —NH2;
• —NHR″;
• —NH—COR″;
• -Hal (halogen);
• —CN;
• —COOR″;
• —COR″;
• with R″ representing a hydrocarbon radical, linear, branched or cyclic, saturated or unsaturated, containing 1 to 6 carbon atoms, optionally halogenated,
• its mineral or organic acid salts, its optical isomers, in isolated form or as a racemic mixture.