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US 7,125,548 B2Granted
Streptococcus suis vaccines and diagnostic tests
AssigneeStichting Dienst Landbouwkundig Onderzoek
InventorHilda Elizabeth Smith
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Abstract
The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an isolated or recombinant nucleic acid encoding a capsular gene cluster of Streptococcus suis or a gene or gene fragment derivated thereof. The invention further provides a nucleic acid probe or primer allowing species or serotype-specific detection of Streptococcus suis. The invention also provides a Streptococcus suis antigen and vaccine derived thereof.
Claims11
A composition, comprising:
- a Streptococcus suis serotype 2 knockout mutant wherein the knockout mutation is in the capsular polysaccharide (cps) gene cluster as set forth in SEQ ID NO:
- 9, wherein the knockout mutation is in the cpsB gene encoding the cpsB protein as set forth in SEQ ID NO:
- 13, the cpsE gene encoding the cpsE protein as set for in SEQ ID NO:16, or the cpsF gene encoding the cpsF protein as set forth in SEQ ID NO:17 or a combination thereof, the knockout mutation causing a deficiency in cellular capsular expression, and
- a pharmaceutically acceptable carrier or adjuvant.
1 more element
Dependencies are inferred from the claim text.