Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy
AssigneeUniversity of Texas System Board of Regents
InventorsPhilip E. Thorpe, Francis J. Burrows
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Abstract
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
Claims15
A method for treating an animal having a vascularized tumor, comprising:
- (a) administering to said animal an amount of a construct effective to treat said vascularized tumor;
- said construct comprising a selected therapeutic agent linked to a targeting agent that binds to a marker expressed, accessible to binding or localized on the cell surfaces of intratumoral blood vessels of the vascularized tumor;
- and
- (b) treating said animal with radiotherapy.
Dependencies are inferred from the claim text.