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US 7,125,478 B2Granted
Microscale electrophoresis devices for biomolecule separation and detection
AssigneeThe Regents of the University of Michigan
InventorsPonnambalam Selvaganapathy, Mark A. Burns, David T. Burke, Carlos H. Mastrangelo
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Abstract
The present invention relates to microfabrication and utilization of microscale electrophoresis devices as well as the separation and detection of biomolecules in microscale electrophoresis devices. The device of the present invention utilizes novel fabrication and detection methods.
Claims11
A device, comprising:
- i) a substrate comprising one or more microchannels;
- ii) a sieving matrix disposed within said one or more microchannels;
- iii) one or more reservoirs in fluidic communication with said one or more microchannels;
- and
- iv) an inline electrochemical detector comprising a working electrode and a counter electrode, wherein said working electrode is substantially surrounded by a reference electrode positioned within at least one of said one or more microchannels.
2 more elements
Dependencies are inferred from the claim text.