Chimeric Arterivirus-like particles
AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsMonique Helene Verheije, Johanna Jacoba M. Meulenberg
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Abstract
The invention relates to the field for Arteriviruses and vaccines directed against infections caused by these viruses. The invention provides an Arteriviruses-like particle comprising at least a first structural protein derived from a first Arterivirus and a second structural protein wherein the second structural protein is at least partly not derived from said first Arterivirus.
Claims3
A process for producing an attenuated porcine reproductive and respiratory syndrome virus (PRRSV), said process comprising:
- substituting a region of a first PRRSV genome encoding M protein ectodomain with a region of a LDV genome encoding M protein ectodomain to create a substituted PRRSV genome,
- wherein M protein ectodomain encoded from the substituted PRRSV genome forms a heterodimer with GP5 encoded from the substituted PRRSV genome.
A process for producing an attenuated porcine reproductive and respiratory syndrome virus (PRRSV), said process comprising:
- removing overlap between ORF5 and ORF6 of a first PRRSV genome;
- and
- substituting a region of the first PRRSV genome that encoding M protein ectodomain with a region of a second Arterivirus genome encoding M protein ectodomain to create a substituted PRRSV genome,
- wherein the second Arterivirus is equine arteritis virus (EAV) or a second PRRSV that is not the same serotype as the PRRSV encoded by the first PRRSV genome, and
- wherein GP5 encoded from the substituted PRRSV genome comprises an intact C-terminus.
Dependencies are inferred from the claim text.