US 7,122,323 B2 · Apparatus and method for synthesizing combinatorial libraries

Abstract

An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-shaped lanterns and gears.

Claims10

Dependent claims

An apparatus for synthesizing a combinatorial library comprising:

a 3-D array of solid-phase supports comprised of a plurality of 2-D frames with means to permit stacking into the 3-D array of solid-phase supports;
wherein the 2-D frames have a plurality of intersecting double-drilled holes formed from first and second adjacent holes, said first hole receiving said solid-phase support in a friction fit attachment and said second hole providing a channel means for delivering reagents to a subset of the 3-D array of solid-phase supports;
and means for removing said solid-phase supports, without disassembling the 3D array.

Dependencies are inferred from the claim text.

Facts

Application

10/316,353Filed 11 Dec 2002 · division

Priority

20 May 1998

Published

US 2003/0068644 A123 Oct 2003

Granted

17 Oct 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification50 codes

G01N 33/543
Immunoassay; Biospecific binding assay; Materials therefor: with an insoluble carrier for immobilising immunochemicals
B01J 19/0046
Chemical, physical or physico-chemical processes in general; Their relevant apparatus: sequential or parallel reactions, e.g. for the synthesis of…
B82Y 30/00
Nanotechnology for materials or surface science
B01J 2219/00286
Individual reactor vessels: reactor vessels with top and bottom openings

Family

Application09/082,038Parent of this continuation-in-part · filed 20 May 1998

Application09/449,222Parent of this division · filed 24 Nov 1999

US 2003/0198999 A1Pre-grant publication · published 23 Oct 2003

US 6,541,211 B1Parent of this division

US 6,872,535 B2Parent of this continuation-in-part

Application09/449,222Parent of this continuation-in-part

US 2003/0068644 A1Published application

US 7,122,323 B2This patent

From the US filing history. Foreign family members aren’t listed.

Apparatus and method for synthesizing combinatorial libraries

Life of this patent

Apparatus and method for synthesizing combinatorial libraries

Life of this patent

Abstract

Claims10