Drynaria extractions for treating osteoporosis and their extraction process
AssigneesQihuang Pharmaceutical Technology and Investment Co., Ltd., Xiyuan Hospital Affiliated to China Academy of TCM.
InventorYanming Xie
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Abstract
Rhizoma Drynariae extract (RDE) is used as therapeutical agent or in the preparation for Osteoporosis, which is characterized in containing over 30 percent of total flavonoids. Furthermore naringin contained in flavonoids is more than 30 percent and less than 100 percent. The RDE is applied for the therapy of osteoporosis or used for producing drugs treating osteoporosis. And methods of extracting the same are also related.
Claims21
An extract from Rhizoma Drynariae, obtained by pulverizing the Rhizoma, agitating and extracting the pulverized Rhizoma in a mixture of water and alcohol, the temperature of which is below 100° C., wherein the alcohol in the mixture is between 20% and 90% of the water and alcohol mixture by volume, wherein the content of total flavonoids, based on the weight of the extract, is 30 percent or more, and the content of naringin thereof, based on the weight of total flavonoids, is 30 percent or more, and less than 100 percent.
A preparation process for a Rhizoma Drynariae extract wherein the content of total flavonoids, based on the weight of the extract, is 30 percent or more, and the content of naringin thereof, based on the weight of total flavonoids, is 30 percent or more, and less than 100 percent, the process comprising the steps of:
- 1) Extraction of Rhizoma Drynariae with water, or a mixture of water and alcohol wherein the alcohol in the mixture is between 20% and 90% of the water and alcohol mixture by volume;
- 2) adsorption of the extractant with resin;
- and
- 3) elution of the resin which has absorbed the extractant with water, alcohol or a mixture thereof.
An extract of Rhizoma Drynariae, prepared by the process of:
- 1) extracting Rhizoma Drynariae using a mixture of water and alcohol, the alcohol concentration being between 20 and 90% by volume;
- 2) adsorbing the extract with a resin;
- and
- 3) after the extract has been adsorbed by said resin, eluting the resin with a mixture of water and alcohol.
A method of extracting Rhizoma Drynariae, comprising the steps of:
- 1) extracting Rhizoma Drynariae using a mixture of water and alcohol, the alcohol concentration being between 20 and 90% by volume;
- 2) adsorbing the extract with a resin;
- and
- 3) after the extract has been adsorbed by said resin, eluting the resin with a mixture of water and alcohol.
An extract from Rhizoma Drynariae, obtained by pulverizing the Rhizoma, agitating and extracting the pulverized Rhizoma in water, the temperature of which is under 100° C., wherein the alcohoi in the mixture is between 20% and 90% of the water and alcohol mixture by volume, wherein the content of total flavonoids, based on the weight of the extract, is 30 percent or more, and the content of naringin thereof, based on the weight of total flavonoids, is 30 percent or more, and less than 100 percent.
Dependencies are inferred from the claim text.