Bioerodable polymeric adhesives for tissue repair
AssigneeDePuy Products, Inc.
InventorsDale R. Peterson, Z. David Deng, Todd P. Glancy
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Abstract
Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
Claims6
An implantable article of manufacture for use in the release of a bioactive agent into a physiological environment, the article comprising a matrix,
- the matrix comprising,
- a thermoplastic terpolymer selected from the group consisting of poly(lactide/glycolide/caprolactone) and poly(lactide/glycolide/valerolactone), the terpolymer having (i) an average molecular weight of 1,000 to 3,000, (ii) a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and (iii) an adhesive strength of about 600 to about 150,000 Pa so that the matrix is tissue adherent, and
- a bioactive agent.
Dependencies are inferred from the claim text.