Microfluidized oil-in-water emulsions and vaccine compositions
AssigneePfizer Inc.
InventorsPaul Joseph Dominowski, Pamela K. Klose, Richard L. Krebs, Ramasamy M. Mannan
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Abstract
This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emulsions and vaccines are also provided by the present invention.
Claims8
A vaccine comprising a saponin glycoside, a sterol and an antigen, wherein said saponin glycoside and said sterol associate with each other to form complexes in the form of helical micelles, and wherein said antigen is in admixture with, but not integrated within, said helical micelles.
Dependencies are inferred from the claim text.