Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates
AssigneeEmory University
InventorsJ. David Lambeth, Guangjie Cheng, James McCoy
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Abstract
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The present invention additionally comprises cells and cell lines containing transgenes encoding for members of the NOX and Duox family of proteins. The present invention further comprises methods and compositions for evaluating regulators of abnormal cell growth and in the development of compounds that effect ROI expression.
Claims11
A transgenic mouse, whose genome comprises a transgene encoding NOX1, wherein the transgene comprises a nucleic acid encoding SEQ ID NO:
- 2 operatively linked to a CX1 promoter, and wherein the mouse exhibits an increased overgrowth of colonic epithelial cells upon exposure to pathogenic bacteria.
Dependencies are inferred from the claim text.