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US 7,119,215 B2Granted
Production method of citalopram, intermediate therefor and production method of the intermediate
AssigneeSumitomo Chemical Company, Limited
InventorsTetsuya Ikemoto, Wei-Guo Gao, Masami Igi
Life of this patent
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Abstract
A compound of formula [V] is prepared by oxidizing a compound of formula [III]. Citalopram can be industrially and economically produced and at a high yield by converting a compound of formula [V], which is prepared from a compound of formula [III], to a compound of formula [VI], and then alkylating the compound of formula [VI] to form citalopram.
Claims8
A method for the preparation of citalopram, which method comprises the steps of
- (a) reducing the compound of formula [II]
- to form a compound of formula [VII]
- (b) cyclizing the compound of formula [VII] to form a compound of formula [III]
- (c) oxidizing the compound of formula [III] to form an aldehyde compound of formula
- (d) converting the aldehyde compound of formula [V] to the corresponding 5-cyano compound of formula [VI]
- (e) alkylating the 5-cyano compound of formula [VI] to form citalopram in the form of a base or an acid addition salt thereof.
3 more elements
Dependencies are inferred from the claim text.