Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives

A compound of formula (A):

• wherein:
• Ar is:
• wherein:
• U is O or S;
• rings A and B are optionally substituted with one to three groups selected from F, cl, Br, I, OR22, OR27, NR23R24, NHOH, NO2, CN, CF3, C1–C6 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, C3–C7 cycloalkyl, 3–7 membered heterocycloalkyl, phenyl, 5 or 6 membered heteroaryl, arylalkyl, C(═O)R22, CO2R22, OC(═O)R22, C(═O)NR23R24, NR21C(═O)R22, NR21CO2R22, OC(═O)NR23R24, NR21C(═S)R22, and S(O)yR22;
• Y is C1–C6 alkylene;
• wherein said alkylene groups are optionally substituted with one to three R20 groups;
• R1 is C(═O)NR12R13,
• R12 and R13 at each occurrence are each independently selected from H, C1–C6 alkyl, or R12 and R13, together with the nitrogen to which they are attached, form a 3–7 membered heterocyclic ring;
• wherein said alkyl groups and heterocyclic ring are optionally substituted with one to three R20 groups;
• R20 at each occurrence is independently selected from F, Cl, Br, I, OR22, OR27, NR23R24, NHOH, NO2, CN, CF3, C1–C6 alkyl optionally substituted with OH, C2–C6 alkenyl, C2–C6 alkynyl, C3–C7 cycloalkyl, 3–7 membered heterocycloalkyl, phenyl, 5 or 6 membered heteroaryl, arylalkyl, ═O, C(═O)R22, CO2R22, OC(═O)R22, C(═O)NR23R24, NR21C(═O)R22, NR21C(═O)OR22, OC(═O)NR23R24, NR21C(═S)R22, and S(O)yR22;
• R21 at each occurrence is independently selected from H and C1–C6 alkyl;
• R22 at each occurrence is independently selected from H, C1–C6 alkyl optionally substituted with OH, arylalkyl and C6–C10 aryl;
• R23 and R24 at each occurrence are each independently selected from H, C1–C6 alkyl, and C6–C10 aryl, or R23 and R24, together with the nitrogen to which they are attached, form a 3–7 membered heterocyclic ring optionally substituted with ═O;
• R27 at each occurrence is independently the residue of an naturally occurred amino acid after the hydroxyl group of the carboxyl group is removed;
• q is 1, or 2;
• y is 0, 1, or 2;
• and the stereoisomeric forms, mixtures of stereoisomeric forms or pharmaceutically acceptable salts forms thereof.