Benzoamide piperidine containing compounds and related compounds

A compound of the formula

• wherein Q is C═NH, C═CH2, C═S, C═O, SO or SO2;
• B is hydrogen, methylene, or ethylene;
• when B is hydrogen, A is CH2, CH(C1–C6)alkyl, or CH(CF3);
• and B is not directly bonded to A;
• when B is methylene or ethylene, A is CH, CH(C1–C6)alkyl or CH(CF3);
• and B is directly bonded to A;
• Y is N and Z is CH, or Y is CH and Z is N;
• G is NH(CH2)q, S(CH2)q or O(CH2)q, wherein q is zero or one;
• with the proviso that when q is zero, G is —NH—, —S— or —O—;
• W is a one carbon linking group (i.e., methylene) or a saturated or unsaturated two or three carbon linking group, wherein each of the foregoing W groups can optionally be substituted with one substituent R7 or two substituents R7 and R6, or W is a one carbon linking group that is substituted with a 2, 3, 4 or 5 carbon chain that together with W, forms a 3, 4, 5 or 6 membered spiro ring, respectively;
• or W is a saturated two carbon chain linking group that forms, together with a separate 1, 2 or 3 carbon chain, a fused 3, 4 or 5 membered ring, respectively;
• or W is a saturated two carbon chain linking group, wherein one of the two carbons in the chain forms, together with a separate 2, 3, 4 or 5 carbon chain, a 3, 4, 5 or 6 membered spiro ring, respectively;
• p is one;
• R3 is selected from hydrogen, COR9, CO2R9, optionally substituted phenyl, and optionally substituted (C1–C8)alkyl wherein one of the CH2 groups of said (C1–C8)alkyl may optionally be replaced with a sulfur, oxygen or carbonyl group and wherein said (C1–C8)alkyl can optionally be unsubstituted or substituted with one to three substituents, independently selected from hydroxy, oxo, phenyl-(C1–C3)alkoxy, phenyl, cyano, halo, optionally substituted heterocyclic rings, NR9COR10, NR9CO2R10, CONR9R10, COR9, CO2R9, NR9R10, and (C1–C6)alkoxy optionally substituted with from one to seven fluorine atoms, preferably with from zero to three fluorine atoms;
• and wherein the heterocyclic ring substituents on the alkyl groups of R3 are selected, independently, from 3 to 7 membered saturated or unsaturated monocyclic rings containing from 1 to 4 ring heteroatoms, and 8 to 12 membered saturated or unsaturated bicyclic rings containing from 1 to 4 ring heteroatoms, wherein said heteroatoms are selected, independently, from oxygen, nitrogen and sulfur, with the proviso that there can not be two adjacent ring oxygen atoms or two adjacent ring sulfur atoms in either the monocyclic or bicyclic heterocyclic rings, and with the proviso that heterocyclic rings formed from NR9R10 or CONR9R10 must contain at least one nitrogen atom;
• and wherein the heterocyclic ring substituents on the alkyl groups of R3 can optionally be unsubstituted or substituted with one or more substituents, independently selected from oxo, hydroxy, thioxo, halo, cyano, phenyl, (CH2)mNR9R10, NR9COR10, (CH2)mOR9, wherein m is zero, one or two, and (C1–C6)alkyl optionally substituted with one or more substituents, independently selected from halo, CF3, methoxy and phenyl;
• and wherein the phenyl groups of R3 and the phenyl substituents in the alkyl groups of R3 can optionally be unsubstituted or substituted with one or more substitutents, independently selected from the group consisting of halo, cyano, nitro, CF3, (CH2)mNR9R10, wherein m is zero, one or two, NR9COR10, NR9CO2R10, CONR9R10, CO2NR9R10, COR9, CO2R9, (C1–C6)alkyl optionally substituted with from one to seven fluorine atoms, preferably with from zero to three fluorine atoms, (C1–C6)alkoxy optionally substituted with from one to seven fluorine atoms, preferably with from zero to three fluorine atoms, and (C2–C6)alkenyl optionally unsusbstituted or substituted with from one to seven fluorine atoms;
• each of R1, R2, R11, R12 and R13 are selected, independently, from hydrogen and (C1–C6)alkyl optionally unsubstituted or substituted with one or more substituents, that are selected independently from hydroxy, oxo, (C1–C6)alkoxy and cyano;
• or R1 and R2, together with the carbon atoms to which they are attached, or R2 and R3, together with the carbon and nitrogen to which they are attached, respectively, form a 5 or 6 membered saturated heterocyclic ring containing one or two heteroatoms that are selected, independently, from nitrogen, oxygen and sulfur, with the proviso that said ring can not contain two adjacent oxygen atoms or two adjacent sulfur atoms;
• or R1 and R2, together with the carbons to which they are attached, form a 5 or 6 membered, saturated or unsaturated carbocyclic ring, and wherein said heterocyclic and carbocyclic rings formed by R1 and R2 or by R2 and R3 can be unsubstituted or substituted with one or more substituents independently selected from halo, oxo, NR9R10, (C1–C6)alkyl optionally unsubstituted or substituted with from one to seven fluorine atoms;
• or R12 and R13, together with the carbon atoms to which they are attached, form a 5 or 6 membered saturated heterocyclic ring containing one or two heteroatoms that are selected, independently, from nitrogen, oxygen and sulfur, with the proviso that said ring can not contain two adjacent oxygen atoms or two adjacent sulfur atoms, or R12 and R13, together with the carbons to which they are attached, form a 5 or 6 membered, saturated or unsaturated carbocyclic ring, and wherein said heterocyclic and carbocyclic rings formed by R12 and R13 can be unsubstituted or substituted with one or more substituents, independently selected from NR9R10, halo, phenyl-S—, phenyl-SO—, phenyl-SO2—, oxo, (C1–C6)alkoxy optionally unsubstituted or substituted with from one to seven fluorine atoms, and (C1–C6)alkyl optionally substituted with from one to seven fluorine atoms;
• with the proviso that no more than one of R1 and R2, R2 and R3, and R12 and R13 can form a ring;
• R4 is selected from phenyl, 2-, 3- or 4-pyridyl, 2- or 3-thienyl, and pyrimidyl, wherein R4 can be optionally substituted with one or more substituents, preferably with zero or one substituent, selected, independently, from halo, (C1–C6)alkyl optionally substituted with from one to seven fluorine atoms, preferably with from zero to three fluorine atoms, (C1–C6)alkoxy optionally unsubstituted or substituted with from one to seven fluorine atoms and (C2–C6)alkenyl optionally unsubstituted or substituted with from one to seven fluorine atoms;
• R5 and R6 are selected, independently, from hydrogen, —SO(C1–C6)alkyl, —SO2—(C1–C6)alkyl, —SO-aryl, —SO2-aryl, CF3, halo, phenyl, phenyl-(C1–C2)alkyl, hydroxy, aryloxy, heteroaryloxy, pyridyl, tetrazolyl, oxazolyl, thiazolyl, (C1–C6)alkoxy optionally substituted with from one to seven fluorine atoms, (C1–C6)alkyl unsubstituted or substituted with one to seven fluorine atoms, and (C1–C6)alkyl unsubstituted or substituted with one or more substituents, selected, independently, from hydroxy, oxo, (C1–C6)alkoxy, phenyl-(C1–C3)alkoxy, phenyl, cyano, chloro, bromo, iodo, NR9R10, NR9COR10, NR9CO2R10, CONR9R10, COR9 and CO2R9;
• R6 and R7 are selected, independently, from —SO(C1–C6)alkyl, —SO2—(C1–C6)alkyl, —SO-aryl, —SO2-aryl, CF3, halo, phenyl, phenyl-(C1–C2)alkyl, hydroxy, aryloxy, heteroaryloxy, pyridyl, tetrazolyl, oxazolyl, thiazolyl, (C1–C6)alkoxy optionally unsubstituted or substituted with from one to seven fluorine atoms, (C1–C6)alkyl optionally unsubstituted or substituted with from one to seven fluorine atoms, and (C1–C6)alkyl substituted with one or more substituents, preferably with from zero to two substituents selected, independently, from hydroxy, oxo, (C1–C6)alkoxy, phenyl-(C1–C3)alkoxy, phenyl, cyano, chloro, bromo, iodo, NR9R10, NR9COR10, NR9CO2R10, CONR9R10, COR9 and CO2R9;
• each R9 and each R10 is selected, independently, from hydrogen, (C1–C6)alkyl, hydroxy(C1–C6)alkyl, phenyl and CF3;
• or R9 and R10, when R3 is NR9R10 or CONR9R10, can form, together with the nitrogen to which they are attached, an optionally substituted heterocyclic ring that contains at least one nitrogen atom;
• and wherein the phenyl groups in the definition of R5, R6, R7 and R8 and the phenyl moiety of phenyl (C1–C2)alkyl in the definition of R5, R6, R7 and R8 can optionally be unsubstituted or substituted with one or more substituents, that are selected, independently, from halo, hydroxy, (C1–C6)alkoxy optionally unsubstituted or substituted with from one to seven fluorine atoms, preferably with from zero to three fluorine atoms, and (C1–C6)alkyl optionally substituted with from one to seven fluorine atoms, preferably with from zero to three fluorine atoms;
• or a pharmaceutically acceptable salt thereof.