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US 7,119,176 B2Granted
Antibodies specific to human prostacyclin synthase
OwnerTadashi Tanabe, Chieko Yokoyamainventors
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OwnerTadashi Tanabe, Chieko Yokoyamainventors
Estimating the term…
The present invention clarifies the primary structure of human-originated PGIS and the nucleotide sequence encoding same. The PGIS and its DNA are useful as reagents for the development of therapeutic agents for the cardiovascular diseases induced by the production imbalance between PGI2 and TXA2, and as diagnostics for determining the in vivo tissue expression level and distribution of PGIS or mRNA thereof. Moreover, they can be used as therapeutic agents for cardiovascular diseases, which introduce PGIS and the like into human or other animals in a lesion-specific manner. The production method of the present invention is useful for the easy and efficient mass production of the human-originated PGIS. The antibody of the present invention is useful for the purification of the human-originated PGIS and immunohistochemical analysis of the cause of a disease.
An isolated or purified antibody that specifically binds an amino acid sequence consisting of residues 1–12 of SEQ ID NO:18.
An isolated or purified antibody that specifically binds an amino acid sequence consisting of residues 1–12 of SEQ ID NO:18, said antibody produced using an immunogen comprising a polypeptide, wherein said polypeptide comprises residues 1–12 of SEQ ID NO:18.
A method for producing an antibody that specifically binds an amino acid sequence consisting of residues 1–12 of SEQ ID NO:18, comprising;
Dependencies are inferred from the claim text.