P. aeruginosa mucoid exopolysaccharide specific binding peptides
AssigneesThe Brigham and Women's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc.
InventorsGerald B. Pier, Michael J. Preston, Lisa Cavacini, Marshall Posner
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Abstract
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
Claims39
A composition, comprising an isolated peptide that selectively binds to P. aeruginosa mucoid exopolysaccharide and comprises an amino acid sequence selected from the group consisting of SEQ ID NO:5 and SEQ ID NO:8 or a variant having at least 95% identity to SEQ ID NO:5 or SEQ ID NO:8.
A composition, comprising an isolated peptide that selectively binds to P. aeruginosa mucoid exopolysaceharide and comprises an amino acid sequence selected from the group consisting of SEQ ID NO:6 and SEQ ID NO:7 or a variant having at least 95% identity to SEQ ID NO:6 or SEQ ID NO:7.
Dependencies are inferred from the claim text.