Methods and compositions for diagnosis and treatment of iron overload diseases and iron deficiency diseases
AssigneesBio-Rad Laboratories, Inc., California Institute of Technology
InventorsJohn N. Feder, Pamela J. Bjorkman, Randall C. Schatzman
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Abstract
Methods and compositions are provided for the diagnosis and treatment of iron overload diseases and iron deficiency diseases.
Claims5
A composition comprising an isolated hereditary hemochromatosis (HFE) polypeptide consisting of the amino acid sequence of SEQ ID NO:1 and a full length, wild-type human β2 microglobulin (β2m).
A composition comprising an isolated HFE polypeptide consisting of the amino acid sequence of SEQ ID NO:2 and a full length, wild-type human β2m.
A composition comprising an HFE polypeptide having the amino acid sequence of SEQ ID NO:3 and a full length, wild-type human β2m.
A composition comprising an isolated HFE polypeptide comprising the amino acid sequence of SEQ ID NO:2 and a full length, wild-type human β2m, wherein the HFE polypeptide and the human β2m are in a secreted soluble complex suitable for administration to a subject.
A composition comprising an isolated HFE polypeptide comprising the amino acid sequence of SEQ ID NO:1 and a full length, wild-type human β2m, wherein the HFE polypeptide and the human β2m are in a secreted soluble complex suitable for administration to a subject.
Dependencies are inferred from the claim text.