Paralytic peptide for use in neuromuscular therapy
AssigneeBioProspecting NB Inc.
InventorsJohn M. Stewart, Bradley J. Steeves, Karl Vernes
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Abstract
The invention relates to a low molecular weight peptide (or suite of related peptides) isolated from the submaxiliary saliva glands of shrews of the species Blarina as a paralytic agent. This novel paralytic agent is useful as a neuromuscular blocker and analgesic or as an insecticide.
Claims20
An isolated peptide from shrew saliva having a molecular weight of 6000 Da on SDS PAGE, wherein the peptide has paralytic activity.
An isolated peptide comprising at least 10 amino acids of the amino acid sequence:
- DCSQDCAACS ILARPAELNT ETCILECEGK LSSNDTEGGL CKEFLHPSKV DLPR (SEQ ID NO:
- 1), wherein the peptide has paralytic activity.
An isolated peptide comprising at least 80% sequence identity with the amino acid sequence of (SEQ ID NO:1), wherein the peptide has paralytic activity.
Dependencies are inferred from the claim text.