Antimicrobially active 4-methyl-4-aryl-2-pentanols, their preparation and use
AssigneeSymrise AG
InventorsGerhard Schmaus, Holger Joppe
Life of this patent
Estimating the term…
Abstract
Antimicrobially active 4-methyl-4-aryl-2-pentanols of the Formula 1 below, methods for the preparation of these compounds and their use as antimicrobial active compounds are described. Surprisingly, compounds of the Formula 1 for which: R=hydrogen, hydroxyl, alkoxy group with up to 10 C atoms, straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms, alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge, fluorine, chlorine, bromine, iodine, or alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms, have proved to be antimicrobially active.
Claims29
Method for the cosmetic and/or therapeutic treatment of (a) microorganisms causing dandruff, (b) microorganisms causing body odour, (c) microorganisms causing acne and/or (d) microorganisms causing mycoses, comprising:
- topically applying to a human or animal body suffering from (a) microorganisms causing dandruff, (b) microorganisms causing body odour, (c) microorganisms causing acne and/or (d) microorganisms causing mycoses, an antimicrobially active amount of one or more compounds of the Formula 1
- wherein R=hydrogen, hydroxyl, alkoxy group with up to 10 C atoms, straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms, alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge, fluorine, chlorine, bromine, iodine, or alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms.
A method for controlling microorganisms by applying to a microbial population comprising microorganisms that cause dandruff an antimicrobially active composition that comprises a compound according to Formula 1
- where R=
- hydrogen,
- hydroxyl,
- alkoxy group with up to 10 C atoms,
- straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms,
- alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge,
- fluorine, chlorine, bromine, iodine, or
- alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms.
A method for controlling microorganisms by applying to a microbial population comprising microorganisms that cause body odour an antimicrobially active composition that comprises a compound according to Formula 1
- where R=
- hydrogen,
- hydroxyl,
- alkoxy group with up to 10 C atoms,
- straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms,
- alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge,
- fluorine, chlorine, bromine, iodine, or
- alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms.
A method for controlling microorganisms by applying to a microbial population that comprises Propionibacterium acnes an antimicrobially active composition that comprises a compound according to Formula 1
- where R=
- hydrogen,
- hydroxyl,
- alkoxy group with up to 10 C atoms,
- straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms,
- alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge,
- fluorine, chlorine, bromine, iodine, or
- alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms.
A method for controlling microorganisms by applying said to a microbial population comprising microorganisms that cause mycoses an antimicrobially active composition that comprises a compound according to Formula 1
- where R=
- hydrogen,
- hydroxyl,
- alkoxy group with up to 10 C atoms,
- straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms,
- alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge,
- fluorine, chlorine, bromine, iodine, or
- alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms.
A deodorant comprising the following components:
- (a) an antimicrobially active amount of one or more compounds of the Formula 1
- where R=
- hydrogen,
- hydroxyl,
- alkoxy group with up to 10 C atoms,
- straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms,
- alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge,
- fluorine, chlorine, bromine, iodine, or
- alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms as well as
- (b) a carrier substance compatible with component (a).
A deodorant comprising a composition which is present in an amount sufficient to suppress growth of odor-causing bacteria on human skin, said composition comprising the following components:
- (a) an antimicrobially active amount of one or more compounds of the Formula 1
- where R=
- hydrogen,
- hydroxyl,
- alkoxy group with up to 10 C atoms,
- straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms,
- alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge,
- fluorine, chlorine, bromine, iodine, or
- alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms as well as
- (b) a carrier substance compatible with component (a).
Dependencies are inferred from the claim text.