Oxazoles as mGluR1 enhancers
AssigneeHoffmann-La Roche Inc.
InventorsJoerg Huwyler, Frederic Knoflach, Eric Vieira, Juergen Wichmann
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Abstract
The invention relates to carboxamide derivatives as defined in the specification and claims, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as mGluR1 enhancers in the treatment and prevention of neurological disorders and diseases, such as Alzheimer's disease and dementia.
Claims21
A compound of formula I
- wherein
- one of R1 and R2 is trifluoromethyl, and the other is hydrogen;
- R3 and R3′ are each independently hydrogen or halogen;
- or a pharmaceutically acceptable salt thereof.
A composition comprising a compound of formula I
- wherein
- one of R1 and R2 signifies trifluoromethyl, and the other one signifies hydrogen;
- R3, R3′ signify, independently from each other, hydrogen or halogen;
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
A method of treating Alzheimer's disease in an individual, comprising administering to the individual an effective amount of a compound of formula I.
A method of treating Parkinson's disease in an individual, comprising administering to the individual an effective amount of a compound of formula I.
A method of treating dementia in an individual, comprising administering to the individual an effective amount of a compound of formula I.
A method of treating amyotrophic lateral sclerosis (ALS) in an individual, comprising administering to the individual an effective amount of a compound of formula I.
A method of treating Huntingdon chorea in an individual, comprising administering to the individual an effective amount of a compound of formula I.
Dependencies are inferred from the claim text.