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US 7,119,106 B2Granted
Pharmaceutical compositions of 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
AssigneeCelgene Corporation
InventorsGeorge W. Muller, David I. Stirling, Roger Shen-Chu Chen
Life of this patent
Estimating the term…
Abstract
Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNFα in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafuoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3 -methylpiperidin-3-yl)-4-aminoisoindoline.
Claims7
A pharmaceutical composition comprising an effective amount of a compound of the formula:
- or an acid addition salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
The pharmaceutical composition of clalm 5, which comprises a sterile injectable solution.
Dependencies are inferred from the claim text.