Activator of peroxisome proliferator-activated receptor delta
AssigneeNippon Chemiphar Co., Ltd.
InventorsShogo Sakuma, Tomio Yamakawa, Takashi Kanda, Seiichiro Masui
Life of this patent
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Abstract
A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B1 represents N, etc.; B2 represents O, etc.; each of X1 and X2 represents O, S, a bond, etc.; Y represents C1-8 alkylene chain; Z represents O or S; R1 represents aryl, etc. which can have substituents; R2 represents C1-8 alkyl, etc.; R3 represents C1-8 alkyl, C2-8 alkenyl, etc.; each of R4 and R5 represents hydrogen, C1-8 alkyl, etc.; and R6 represents hydrogen, etc.; provided that each of Z and R3 is attached to the benzene ring, and X2 is not attached to the benzene ring).
Claims10
A compound having the following formula (I) or a salt thereof:
- (wherein A is O, S or NR7 in which R7 is hydrogen or C1-8 alkyl;
- B1 is CW or N in which W is hydrogen or a bond;
- B2 is O, S or NR8 in which R8 is hydrogen or C1-8 alkyl;
- each of X1 and X2 is O, S, NH, NHC(═O), C(═O), C(═N—OR9), CH(OR10), C═C, C≡C or a bond in which each of R9 and R10 is hydrogen or C1-8 alkyl;
- Y is a C1-8 alkylene chain, which can be substituted with C1-8 alkyl or C1-8 alkyl substituted with 1–3 halogens;
- Z is NH, O or S
- R1 is aryl, which can be substituted with a group or atom selected from the group consisting of C1-8 alkyl, C1-8 alkoxy, C1-8 alkyl substituted with 1–3 halogens, hydroxyl, nitro, amino, phenyl, pyridyl and halogen, or a heterocyclic group having five to eight membered ring comprising one to three hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur and the other atoms consisting of carbon (benzene ring can be condensed with the heterocyclic ring);
- R2 is C2-8 alkyl, C1-8 alkyl substituted with 1–3 halogens, C3-7 cycloalkyl, C2-8 alkenyl, C2-8 alkynyl, alkyl (comprising C1-4 alkyl moiety) substituted with aryl, which can be substituted with a group or atom selected from the group consisting of C1-8 alkyl, C1-8 alkoxy, C1-8 alkyl substituted with 1–3 halogens, hydroxyl, nitro, amino, phenyl, pyridyl and halogen, or alkyl (comprising C1-4 alkyl moiety) substituted with a heterocyclic group having five to eight membered ring (comprising one to three hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur and the other atoms consisting of carbon);
- R3 is halogen, trifluoromethyl, C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl;
- each of R4 and R5 is hydrogen, C1-8 alkyl or C1-8 alkyl substituted with 1–3 halogens;
- and
- R6 is hydrogen, C1-8 alkyl substituted with amino, C1-8 alkyl or alkali metal;
- provided that each of Z and R3 is attached to the benzene ring, and X2 is not attached to the benzene ring.
Dependencies are inferred from the claim text.