Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses

A compound of formula (I):

• wherein:
• R1 is
• (a) phenyl or heteroaryl selected from furanyl, thienyl, pyridyl, pyrrolyl, imidazolyl and benzofuranyl, optionally substituted with one to two R4,
• (b) heterocyclyl selected from 1-piperidinyl, 1-piperazinyl, 1-pyrrolidinyl and 4-morpholinyl, optionally substituted with one to two groups selected from C1-6alkyl, —CO2C1-5alkyl, phenyl, benzyl, —OH and —C(O)heteroaryl, wherein the heteroaryl is selected from furanyl, thienyl, pyridyl and pyrrolyl,
• (c) R7(CH2)mO—,
• (d) R7OCH2—,
• (e) R7(CH2)mNH—,
• (f) R7(CH2)p(CH═CH)m—,
• (g) C1-6alkyl, optionally partially or fully halogenated and optionally substituted with one to two R8,
• (h) C1-8alkoxy, optionally partially or fully halogenated and optionally substituted with one to two R8,
• (i) C1-8alkylS(O)n—, optionally partially of fully halogenated and optionally substituted with one to two R8,
• (j) —N(R5)(R6), or
• (k) —C(O)NHR′, wherein R′ is R7, pyridyl or —CH3;
• R2 is heteroaryl selected from the group consisting of furanyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, indolizinyl, indolyl, isoindolyl, benzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzthiazolyl, benzoxazolyl, purinyl, quinolizinyl, quinolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, naphthyridinyl, pteridinyl, carbazolyl, acridinyl, phenazinyl, phenothiazinyl and phenoxazinyl, substituted with one to three R4;
• R3 is —OH or —H;
• R4 is chosen from, C1-6alkoxy, hydroxyC1-6alkyl, halogen, —CN, —CO2H, —CO2C1-6alkyl, —S(O)C1-6alkyl, —S(O)n-p-tolyl, —NO2, —OH, —CF3, —N(R5)(R6), —NHC(O)NHC1-6alkyl, —C(O)N(R5)(R6)—, and R9;
• R5 and R6 are independently selected from H, C1-6alkyl, —C(O)C1-6alkyl, —SO2C1-6alkyl, phenyl, pyridyl, benzyl, piperidinyl, phenylethyl and (CH3)3COC(O)—;
• R7 is a phenyl group optionally substituted with one or two groups selected from halogen, C1-6alkyl, —CN, —CO2C1-6alkyl, —C(O)NR5R6, —SO2NH2, —NO2, —OH, —NH2, —CF3 and C1-6alkoxy, or R7 is C3-6cycloalkyl, —CH2OH, naphthalene-2-yl, naphthalene-1-yl, pyridyl or thienyl;
• R8 is selected from oxo, —OH, —NR4R5, —CO2H and C1-6alkoxy;
• R9 is is a heteroaryl selected from the group of furanyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, indolizinyl, indolyl, isoindolyl, benzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzthiazolyl, benzoxazolyl, purinyl, quinolizinyl, quinolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, naphthyridinyl, pteridinyl, carbazolyl, acridinyl, phenazinyl, phenothiazinyl and phenoxazinyl and methyl imidizolyl, carbanomethylsulfanyl, methoxypiperdinyl, methoxypyridinyl, bromopyridynyl and methoxypyrimidynyl;
• m is 0 or 1;
• n is 0, 1 or 2;
• p is 0, 1, 2 or 3;
• Z is a bond or —O—CH2—;
• or a pharmaceutically acceptable salt, ester, tautomer, individual isomers, and mixtures of isomers thereof.