Chemical compounds
AssigneeSmithKline Beecham Corporation
InventorsGiuseppe Alvaro, Paolo Maragni, Marsia Tampieri
Life of this patent
Estimating the term…
Abstract
wherein R represents a halogen atom or a C1-4 alkyl group; R1 represents a C1-4 alkyl group; R2 represents hydrogen or a C1-4 alkyl group; R3 represents hydrogen, or a C1-4 alkyl group; R4 represents a trifluoromethyl group; R5 represents hydrogen, a C1-4 alkyl group or C(O)R6; R6 represents C1-4 alkyl, C3-7 cycloalkyl, NH(C1-4 alkyl) or N(C1-4alkyl)2; m is zero or an integer from 1 to 3; n is an integer from 1 to 3 and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation and their use in the treatment of conditions mediated by tachykinins.
Claims41
4-(S)-(4-Acetyl-piperazin-1-yl)-2-(R)-(4-fluoro-2-methyl-phenyl)-piperidine-1-carboxylic acid, [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide methanesulphonate.
A method for the treatment of a major depressive disorder in a mammal in need thereof comprising administering to said mammal an effective amount of 4-(S)-(4-Acetyl-piperazin-1-yl)-2-(R)-(4-flouro-2-methyl-phenyl)-piperidine-1-carboxylic acid, [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide methanesulphonate.
A method for the treatment of anxiety in a mammal in need thereof comprising administering to said mammal an effective amount of 4-(S)-(4-Acetyl-piperazin-1-yl)-2-(R)-(4-flouro-2-methyl-phenyl)-piperidine-1-carboxylic acid, [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide methanesulphonate.
A method for the treatment of panic disorder in a mammal in need thereof comprising administering to said mammal an effective amount of 4-(S)-(4-Acetyl-piperazin-1-yl)-2-(R)-(4-flouro-2-methyl-phenyl)-piperidine-1-carboxylic acid, [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide methanesulphonate.
A method for the treatment of emesis in a mammal in need thereof comprising administering to said mammal an effective amount of 4-(S)-(4-Acetyl-piperazin-1-yl)-2-(R)-(4-flouro-2-methyl-phenyl)-piperidine-1-carboxylic acid, [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide methanesulphonate.
Dependencies are inferred from the claim text.