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US 7,119,088 B2Granted
Triazole compounds useful in therapy
AssigneePfizer Inc.
InventorsJustin Stephen Bryans, Patrick Stephen Johnson, Thomas Ryckmans, Alan Stobie
Life of this patent
Estimating the term…
Abstract
A compound of formula (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, V, W, X, Y, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof.
Claims19
A compound of formula (I),
- or a pharmaceutically acceptable salt, solvate, ester, or amide thereof, wherein
- V represents —(CH2)d(O)e—, —CO—, or —CH(C1-6 alkyl)—;
- W is —O—, —S(O)a—, or —N(R1)—
- R1 represents H, C1-6 alkyl, (CH2)bCOR2, CO(CH2)bNR2R3, SO2R2, (CH2)cOR2, (CH2)cNR2R3, or (CH2)bhet1;
- het1 represents a saturated or unsaturated heterocycle of from 3 to 8 atoms containing one or more heteroatoms selected from O, N, or S, optionally substituted with C1-6 alkyl;
- X and Y independently represent H, C1-6 alkyl, halogen, OH, CF3, OCF3, OR4;
- Z represents —(CH2)f(O)g—, —CO— or —CH(C1-6 alkyl)—;
- Ring A represents a 4–7 membered, saturated N-containing heterocycle, optionally substituted with OH, and in which optionally at least one ring N is substituted with O;
- Ring B represents phenyl or a 4–7 membered unsaturated N-containing heterocycle, optionally substituted with OH, halogen, CN, CONH2, CF3, OCF3, and in which optionally at least one ring N is substituted with O;
- R2 and R3 independently represent H, C1-6 alkyl [optionally substituted with OH, halogen, N(C1-6 alkyl)2, or C1-6 alkyloxy], C1-6 alkyloxy, N(C1-6 alkyl)2, or [C3-8 cycloalkyl];
- or R2 and R3, together with the nitrogen atom to which they are attached independently represent a heterocycle of from 3 to 8 atoms, optionally substituted with C1-6 alkyl;
- R4 represents straight or branched C1-6 alkyl;
- a and c independently represent 0, 1, or 2;
- b, e and g independently represent 0 or 1;
- and
- d and f independently represent 1 or 2.
13 more elements
Dependencies are inferred from the claim text.