Bioadhesive pharmaceutical compositions
OwnerDonald L. Barbeauinventor
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds having the formula wherein R2 is hydrogen, a monomeric glycoside or an oligomeric glycoside, R3 is hydrogen, a monomeric glycoside, an oligomeric glycoside, or a group having the formula R is a lower alkylene, R′ is selected from the group consisting of moieties having the formula where X=0 or 1, Y=0 or 1, R1 is hydrogen or a pharmacologically active drug residue, R8 a pharmacologically active drug residue, R4, R5, and R6 are independently hydrogen, alkyl, aryl, aralkyl, and cycloalkyl or together form a nitrogen-containing ring, and R7 is hydroxyl or hydroxyalkyl.
Claims19
A compound having the formula
- wherein R2 and R3 are independently hydrogen, or a glycoside having the formula
- where n=0 to 8 and R9 is an alkyl, alkylene, monocationic alkylamine or polycationic alkylamine, where R is a lower alkylene, where R′ is
- where X=0 or 1, Y=0 or 1, R1 is hydrogen or a pharmacologically active drug residue, and R4, R5, and R6 are independently hydrogen, alkyl, aryl, aralkyl, cycloalkyl or together form a nitrogen-containing ring selected from the group consisting of
- with the proviso that said compound contains at least one pharmacologically active drug residue, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition useful for the treatment of inflammatory disease or for reducing inflammation which composition comprises an inflammation reducing effective amount of a compound having the formula
- where X=0 or 1, Y=0 or 1, R is an alkylene having from 1 to about 6 carbon atoms or a heteroalkylene containing carbon, nitrogen and oxygen atoms, R1 is hydrogen or a pharmacologically active drug residue, R4, R5, and R6 are independently hydrogen, alkyl, aryl, or aralkyl, and n=0 to about 8, with the proviso that said compound contains at least one pharmacologically active drug residue or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition useful for the treatment of infectious disease or for reducing infection which composition comprises an infection reducing effective amount of a compound having the formula
- where X=0 or 1, Y=0 or 1, R is an alkylene having from 1 to about 6 carbon atoms or a heteroalkylene containing carbon, nitrogen and oxygen atoms, R1 is hydrogen or a pharmacologically active drug residue, R4, R5, and R6 are independently hydrogen, alkyl, aryl, or aralkyl, and n=0 to about 8, with the proviso that said compound contains at least one pharmacologically active drug residue or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition useful for the treatment of glaucoma or for reducing intraocular pressure which composition comprises a therapeutically effective amount of a compound having the formula
- where X=0 or 1, Y=0 or 1, R is an alkylene having from 1 to about 6 carbon atoms or a heteroalkylene containing carbon, nitrogen and oxygen atoms, R1 is hydrogen or a pharmacologically active drug residue, R4, R5, and R6 are independently hydrogen, alkyl, aryl, or aralkyl, and n=0 to about 8, with the proviso that said compound contains at least one pharmacologically active drug residue or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition useful for administering therapeutic compositions occularly for the treatment of systemic disorders, which composition comprises a therapeutically effective amount of a compound having the formula
- where X=0 or 1, Y=0 or 1, R is an alkylene having from 1 to about 6 carbon atoms or a heteroalkylene containing carbon, nitrogen and oxygen atoms, R1 is hydrogen or a pharmacologically active drug residue, R4, R5, and R6 are independently hydrogen, alkyl, aryl, or aralkyl, and n=0 to about 8, with the proviso that said compound contains at least one pharmacologically active drug residue or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition useful for the treatment of an oncology disease or for reducing tumors which composition comprises a tumor reducing effective amount of a compound having the formula
- where X=0 or 1, Y=0 or 1, R is an alkylene having from 1 to about 6 carbon atoms or a heteroalkylene containing carbon, nitrogen and oxygen atoms, R1 is hydrogen or a pharmacologically active drug residue, R4, R5, and R6 are independently hydrogen, alkyl, aryl, or aralkyl, and n=0 to about 8, with the proviso that said compound contains at least one pharmacologically active drug residue or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.