Technology of intracellular delivery of DNA oligonucleotides to improve drug activity
AssigneeBaylor College of Medicine
InventorsNaijie Jing, Weijun Xiong, Yongli Guan
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Abstract
The present invention relates to methods of intracellular delivery of oligonucleotides. More particularly, the present invention relates to the use of the delivery system to deliver G-quartet oligonucleotides as a cancer therapy or an anti-viral therapy.
Claims15
A method of inhibiting hyperproliferative cell growth comprising administering to a cell an effective amount of a G-rich oligonucleotide which comprises SEQ ID NO. 2, which G-rich oligonucleotide forms a G-quartet structure and inhibits DNA binding activity of a signal transducer and activator of transcription 3 (STAT3) protein thereby inhibiting hyperproliferative cell growth.
A method of treating a hyperproliferative disease comprising administering to a patient an effective amount of a G-rich oligonucleotide which comprises SEQ. ID. NO. 2, which G-rich oligonucleotide forms a G-quartet structure and inhibits DNA binding activity of a signal transducer and activator of transcription 3 (STAT3) protein treating the hyperproliferative disease.
A method of treating a hyperproliferative disease comprising administering to a patient an effective amount of a composition comprising a G-rich oligonucleotide which comprises SEQ. ID. NO. 2, which G-rich oligonucleotide forms a G-quartet structure and inhibits DNA binding activity of a signal transducer and activator of transcription 3 (STAT 3) protein, and which composition is administered in combination with chemotherapy, immunotherapy, surgery, or radiotherapy.
Dependencies are inferred from the claim text.