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US 7,119,061 B2Granted
Dalbavancin compositions for treatment of bacterial infections
AssigneeVicuron Pharmaceuticals Inc.
InventorMartin Stogniew
Life of this patent
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Abstract
The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimes include once weekly administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection.
Claims10
A dry formulation comprising:
- dalbavancin;
- at least one stabilizer that is a sugar;
- wherein the formulation has a pH of about 4–5;
- wherein the formulation contains no more than about 5% MAG by weight after about three months at 40° C.
1 more element
A dry formulation comprising:
- dalbavancin;
- a stabilizer comprising lactose and mannitol;
- wherein the formulation pH is about 4.5;
- wherein the formulation contains no more than about 4% MAG by weight after about three months at 40° C.;
- and
- wherein the formulation is freeze-dried.
3 more elements
Dependencies are inferred from the claim text.