System and method for immunosensor regeneration
AssigneeUniversity of South Florida
InventorsShekhar Bhansali, Beverly A. Rzigalinski, Hyoungjin Cho
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Abstract
The present invention allows for regeneration of any chemical and biological sensor systems without totally destroying the primary antibodies in the system. The present invention provides regeneration of the sensor by debinding of the antigen/antibody complex utilizing a controlled electrical impulse. The technique is generic and can be used with most immunoassay-based detectors.
Claims5
A method of regenerating an immunosensor comprising the step of applying at least one electrical pulse to a bound antibody-antigen complex of an immunosensor whereby the complex debinds responsive to the at least one pulse.
A system for the regeneration of an immunosensor, the system comprising:
- an immunosensor having at least one bound antibody-antigen complex on a surface of the immunosensor;
- an electrophoretic manipulator comprising an electrical pulse applicator, the electrophoretic manipulator positioned to apply at least one electrical pulse to the surface of the immunosensor whereby the complex debinds responsive to the at least one pulse.
Dependencies are inferred from the claim text.