Incorporation and applications of biomolecular interactions within a carrier
AssigneeMcMaster University
InventorsJohn D. Brennan, Christopher V. W. Hogue
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Abstract
Described is a carrier having a biomolecular interaction incorporated therein. The carrier is described as comprising a silica based glass and in an embodiment is a sol-gel derived glass. Also described are methods of incorporating biomolecular interaction within a carrier of the invention. Various types of biomolecular interaction are discussed as well as applications of carriers containing one or more biomolecular interactions.
Claims20
A carrier comprising a matrix of an inorganic glass or a hybrid organic-inorganic glass, wherein the matrix contains complex of two or more biological species entrapped within the matrix, wherein the complex is formed before entrapment in the matrix and comprises two or more biological species that can be reversibly dissociated from the other under dissociating conditions, wherein the biological species are selected from the group consisting of proteins, polypeptides, peptides, amino acids, DNA, RNA and phospholipids and wherein the carrier has a pore size that is selected to inhibit leaching out of the complex of two or more biological species or biological species thereof.
Dependencies are inferred from the claim text.