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US 7,118,916 B2Granted
Method of reducing analysis time of endpoint-type reaction profiles
AssigneeLifeScan, Inc.
InventorDavid Matzinger
Life of this patent
Estimating the term…
Abstract
Methods, devices and kits for facilitating medical diagnostic assays and reducing the time required for taking of such assays. The methods comprise initiating a reaction, obtaining at least three measurements, at three different time points, of a value or level of an observable associated with the reaction, and estimating an end point value for the observable from the measurements.
Claims18
A method for characterizing reaction end point, comprising:
- (a) initiating a chemical reaction including an observable A indicative of extent of reaction,
- (b) measuring first, second and third values A1, A2, and A3 for said observable, at times t1, t2 and t3 respectively wherein the time interval t2−t1 is substantially equal to the time interval (t3−t2);
- and
- (c) determining an endpoint value A∞ for said observable according to the relationship
- A
- ∞
- ≅
- A
- 2
- -
- (
- A
- 3
- -
- A
- 1
- )
- 2
- 4
-
- (
- A
- 3
- -
- 2
-
-
- A
- 2
- +
- A
- 1
- )
- .
31 more elements
A system for characterizing a reaction end point, comprising:
- (a) stored programming capable of inputting first, second and third values A1, A2, and A3 measured at times t1, t2 and t3 respectively, for an observable associated with a chemical reaction and the time intervals t2−t1 and t3−t2 are substantially equal;
- and
- (b) stored programming capable of determining an endpoint value A∞ for said observable according to the relationship
- A
- ∞
- ≅
- A
- 2
- -
- (
- A
- 3
- -
- A
- 1
- )
- 2
- 4
-
- (
- A
- 3
- -
- 2
-
-
- A
- 2
- +
- A
- 1
- )
- .
30 more elements
Dependencies are inferred from the claim text.