Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
AssigneeSPI Pharma, Inc.
InventorsGary Telfer Norman, Kalyan S. Nuguru, Arun F. Amin, Sarath Chandar
Life of this patent
Estimating the term…
Abstract
The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.
Claims25
A method for producing a directly compressible quick-dissolving composition, said method comprising:
- a) dissolving mannitol powder and sorbitol powder into a solution;
- b) dry feeding a blend of dry mannitol powder and dry sorbitol powder in the same proportion as the mannitol and sorbitol in the solution of step (a), into a spray drying chamber;
- c) drying the mixture in an air stream;
- d) forming particles having a nonfilamentous microstructure from the mixture;
- and
- e) diluting the resulting particles with a disintegrant, thereby forming a directly compressible quick-dissolving composition.
Dependencies are inferred from the claim text.