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US 7,118,763 B2Granted
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
AssigneesAlkermes Controlled Therapeutics Inc. II, Janssen Pharmaceutica NV
InventorsJean Mesens, Michael E. Rickey, Thomas J. Atkins
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Abstract
Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.
Claims2
A method of making a multi-phasic sustained-release microparticle composition, comprising:
- dissolving in a solvent an active agent and a biodegradable and biocompatible polymer to form an organic phase, wherein the active agent is selected from the group consisting of risperidone, 9-hydroxy-risperidone, and pharmaceutically acceptable acid addition salts of the foregoing;
- extracting the solvent to form microparticles;
- and
- combining microparticles having a plurality of sizes to thereby form a composition that delivers the active agent in a multi-phasic manner.
1 more element
A method of making a multi-phasic sustained-release microparticle composition, comprising:
- dissolving in a solvent an active agent and a biodegradable and biocompatible polymer to form an organic phase, wherein the active agent is selected from the group consisting of risperidone, 9-hydroxy-risperidone, and pharmaceutically acceptable acid addition salts of the foregoing;
- extracting the solvent to form microparticles;
- and
- combining microparticles exhibiting diffusional release and microparticles exhibiting biodegradation release to thereby form a composition that delivers the active agent in a multi-phasic manner.
1 more element
Dependencies are inferred from the claim text.