Herpes viruses for immune modulation
AssigneeBiovex Limited
InventorRobert S. Coffin
Life of this patent
Estimating the term…
Abstract
An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune response when dendritic cells are infected with the virus.
Claims26
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes simplex virus (HSV) which:
- lacks a functional vhs gene;
- lacks a functional gene encoding ICP47;
- and
- lacks a functional ICP34.5 gene.
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes simplex virus (HSV) which:
- (i) lacks a functional vhs gene;
- (ii) lacks a functional gene encoding ICP47;
- (iii) lacks a functional ICP34.5 gene;
- and
- (iv) comprises a functional UL43 gene.
Dependencies are inferred from the claim text.