US 7,118,749 B2 · Transferrin receptor genes

Abstract

Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.

Claims6

Dependent claims

An immunogenic composition comprising not more than one synthetic peptide having no less than six amino acids and no more than 150 amino acids, and a pharmaceutically acceptable carrier thereof;

wherein the synthetic peptide is comprised of the amino acid sequence, LEGGFYGP (SEQ ID NO:
74) or LEGGFYG (SEQ ID NO:
85), and which produces an immune response when administered to a host.

Dependencies are inferred from the claim text.

Facts

Application

10/043,344Filed 14 Jan 2002 · continuation

Priority

8 Nov 1993

Published

US 2003/0088086 A18 May 2003

Granted

10 Oct 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07K 14/285
From bacteria: from Pasteurellaceae , e.g. Haemophilus influenza
A61P 31/00
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents
A61K 39/00
Medicinal preparations containing antigens or antibodies

Family

Application08/148,968Parent of this continuation-in-part · filed 8 Nov 1993

Application08/175,116Parent of this continuation-in-part · filed 29 Dec 1993

Application08/337,483Parent of this continuation-in-part · filed 8 Nov 1994

Application08/483,577Parent of this continuation-in-part · filed 7 Jun 1995

Application08/649,518Parent of this continuation · filed 17 May 1996

US 2003/0088086 A1Pre-grant publication · published 8 May 2003

US 6,361,779 B1Parent of this continuation

US 6,015,688 AParent of this continuation-in-part

Application08/649,518Parent of this continuation-in-part

US 5,922,562 AParent of this continuation-in-part

US 7,118,749 B2This patent

From the US filing history. Foreign family members aren’t listed.

Transferrin receptor genes

Life of this patent

Transferrin receptor genes

Life of this patent

Abstract

Claims6