Drugs for the diagnosis of tissue reproductive activity or the treatment of proliferative diseases
AssigneeNihon Medi-Physics Co., Ltd.
InventorsJun Toyohara, Akio Hayashi
Life of this patent
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Abstract
An agent which comprises, as an active ingredient, a radiolabeled compound as represented by the following formula or a pharmaceutically acceptable salt thereof: wherein R1 denotes hydrogen, or a linear- or branched-chain alkyl group having 1–8 carbon atoms, R2 denotes hydrogen, hydroxyl or a halogen substituent, R3 denotes hydrogen or fluorine substituent, R4 denotes oxygen, sulfur, or a methylene substituent, and R5 denotes a radioactive halogen substituent. The agent is stable in vivo, and either stays in cells or is incorporated in DNA, thus serving for diagnosis of tissue proliferation activity or treatment of proliferative disease.
Claims9
A method for diagnosis of tissue proliferation activity comprising:
- administering an effective amount of an agent for diagnosis of tissue proliferation activity to a mammal, said agent comprising, as an active ingredient, a radiolabeled compound as represented by the following formula or a pharmaceutically acceptable salt thereof:
- wherein R1 denotes hydrogen, or a linear- or branched-chain alkyl group having 1–8 carbon atoms;
- R2 denotes hydrogen, hydroxyl, or a halogen substituent;
- R3 denotes hydrogen or a fluorine substituent, R4 denotes oxygen, sulfur or a methylene substituent, and R5 denotes a radioactive halogen substituent, excluding the case where R1 is hydrogen and R4 is oxygen, and
- imaging in vivo the distribution of said agent,
- wherein said diagnosis of tissue proliferation activity is a diagnosis for hyperplasia, tissue regeneration, tissue transplantation or viral infection accompanied by abnormal proliferation.
A nucleoside derivative as represented by the following formula:
- wherein R1 denotes hydrogen or a linear- or branched-chain alkyl groups having 1–8 carbon atoms, R2 denotes hydrogen, hydroxyl or a halogen substituent, R3 denotes hydrogen or a fluorine substituent, R4, denotes oxygen, sulfur or a methylene substituent, and R5 denotes a trialkylstannyl group, excluding the case where R1 is hydrogen and R4 is oxygen.
Dependencies are inferred from the claim text.