Quinoline derivative as diagnostic probe for disease with tau protein accumulation
AssigneeBf Research Institute, Inc.
InventorsYukitsuka Kudo, Masako Suzuki, Takahiro Suemoto, Nobuyuki Okamura, Tsuyoshi Shiomitsu, Hiroshi Shimazu
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Abstract
The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which β-sheet structure is the cause or possible cause.
Claims31
A compound, or salts or solvates thereof, represented by the formula I(a) or I(b):
- wherein,
- R1, R2, and R3 independently are hydrogen, halogen, OH, COOH, SO3H, NH2, NO2, CO—NH—NH2, alkyl having 1 to 4 carbons (hereinafter, referred to as C1-4alkyl), or O—C1-4alkyl, wherein two R1s, together, may form a benzene ring;
- R4 and R5 independently are hydrogen or C1-4alkyl;
- and
- m and n independently are an integer of 0 to 4;
- and
- wherein said compound is labeled with a radionuclide.
Dependencies are inferred from the claim text.