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US 7,118,710 B2Granted
Label-free high-throughput optical technique for detecting biomolecular interactions
AssigneeSRU Biosystems, Inc.
InventorBrian Cunningham
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Abstract
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
Claims5
A biosensor comprising:
- (a) a two-dimensional grating comprised of a material having a high refractive index, wherein the two-dimensional grating is comprised of a repeating pattern of lines;
- (b) a substrate layer that supports the two-dimensional grating;
- and
- (c) one or more specific binding substances immobilized on the surface of the two-dimensional grating opposite of the substrate layer;
- wherein, when the biosensor is illuminated a resonant grating effect is produced on the reflected radiation spectrum, and wherein the depth and period of the two-dimensional grating are less than the wavelength of the resonant grating effect.
2 more elements
Dependencies are inferred from the claim text.