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US 7,117,100 B2Granted
Method for the compositional analysis of polymers
AssigneeMassachusetts Institute of Technology
InventorsGanesh Venkataraman, Zachary Shriver, Rahul Raman, Ram Sasisekharan, Nishla Keiser
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Abstract
The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
Claims6
A method for compositional analysis of chemical units of a sample polymer, comprising:
- (A) applying an experimental constraint to the sample polymer to modify the sample polymer,
- (B) detecting a property of the modified sample polymer;
- (C) comparing the modified sample polymer to a reference database of polymers of identical size as the polymer, wherein the polymers of the reference database have also been subjected to the same experimental constraint as the sample polymer, wherein the comparison provides a compositional analysis of the sample polymer.
Dependencies are inferred from the claim text.